Paul Jasper

Education

• Post-Doctoral Associate Department of Biology & Bioengineering M.I.T., July 2004 - Present

• Ph.D. Department of Microbiology & Immunology Loyola University Chicago, April 2004

• B. S., Biotechnology Worcester Polytechnic Institute, 1997

Research Interests

Systems Biology of EGFR Signaling --Currently researching EGFR network circuitry using a combination of high-throughput signal transduction assays and data driven molecular modeling to understand EGFR-driven cancer development. Using a panel of EGFR mutant cell lines from the recent lung cancer literature as well as genetically modified mice, we are interrogating system dynamics of the EGFR network in response to different EGFR ligands and small molecule inhibitors. In parallel, we perform mathematical modeling of EGFR network dynamics. Through this comprehensive systems biology approach, we hope to gain insight into EGFR network dynamics and next generation EGFR inhibitor drug design.

Primary Collaborators

Dr. Matthew Lazzara, Lauffenburger Lab
Gordon Lu, Sorger Lab
Keara Lane, Jacks Lab
Dr. Birgit Schoeberl, Merrimack Pharmaceutical

Publications:

Lanning, D., P. Jasper, and K.L. Knight (2002). "IgH haplotype exclusion in rabbits." Seminars in Immunology 14:163-8; discussion 220-1.

Jasper, P., S. Zhai, S. Kalis, M. Kingzette, and K.L. Knight (2003). “B Lymphocyte Development in Rabbit: Progenitor B cells and Waning of B Lymphopoiesis.” Journal of Immunology 171(12): 6372-6380.

Jasper, P.*, K. Rhee*, S. Kalis, P. Sethupathi, and K.L. Knight (2004). “B Cell Deficient -transgenic Rabbits” (manuscript in prep.)
* - These two authors contributed equally to this work

Rhee, K.*, P. Jasper*, P. Sethupathi, M. Shanmugam, D. Lanning, and K.L. Knight (2004). “Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues.” Journal of Experimental Medicine 201(1):55-62.
* - These two authors contributed equally to this work