Arthur Goldsipe

Education

Postdoctoral Associate in Biological Engineering, MIT
PhD in Chemical Engineering from MIT
BS and MS in Chemical Engineering from Tennessee Technological University

Research

The p38 mitogen-activated protein kinase (MAPK) pathway, like the JNK pathway, plays an important role in varied cellular responses, including apoptosis, stress response, and inflammation. p38 and its downstream proteins are promising targets for inhibitors in the treatment of inflammatory diseases like rheumatoid arthritis. I am interested in developing computational and mathematical models to gain insight into the p38 pathway. My initial models use data-driven approaches, like partial least-squares regression (PLSR), to analyze the dynamics of inflammatory signaling and cytokine release. In the future, I plan to use Boolean and fuzzy logic models to incorporate prior knowledge and mechanistic hypotheses, with the goal improving safety and efficacy of anti-inflammatory pharmaceuticals.

Publications

J. Saez-Rodriguez, A. Goldsipe, J. Muhlich, L.G. Alexopoulos, B. Millard, D.A. Lauffenburger, and P.K. Sorger. Flexible Informatics for Linking Experimental Data to Mathematical Models via DataRail. Bioinformatics, (in press).
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Collaborators

Julio Saez-Rodriguez, Chris Espelin, Bree Aldridge, Ben Cosgrove, Leonidas Alexopoulos, Mingsheng Zhang, Jeremy Muhlich