Featured Publications

Key Publications

1. Albeck, J. G., Burke, J. M., Lauffenburger, D. A., and Sorger, P. K. (2008; in revision). Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol.
2. Burg, T., Godin, M., Knudsen, S., Shen, W., Carlson, G., Foster, J., Babcock, K., and Manalis, S. (2007). Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446, 1066-1069. PMID:17460669
   PDFExternal link to articleSupplemental material
3. Kemp, M. L., Wille, L., Lewis, C. L., Nicholson, L. B., and Lauffenburger, D. A. (2007). Quantitative Network Signal Combinations Downstream of TCR Activation Can Predict IL-2 Production Response. J Immunol 178, 4984-4992. PMID:17404280
   PDFExternal link to article
4. Miller-Jensen, K., Janes, K. A., Brugge, J. S., and Lauffenburger, D. A. (2007). Common effector processing mediates cell-specific responses to stimuli. Nature 448, 604-608. PMID:17637676
   PDFExternal link to article
5. Heinrichs, A., Kritikou, E., Pulverer, B., and Raftopoulou, M., eds. (2006). Systems biology: a user's guide (New York, NY: Nature Publishing Group).
   External link to article
6. Janes, K. A., Gaudet, S., Albeck, J. G., Nielsen, U. B., Lauffenburger, D. A., and Sorger, P. K. (2006). The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124, 1225-1239. PMID:16564013
   PDFExternal link to article
7. Wolf-Yadlin, A., Kumar, N., Zhang, Y., Hautaniemi, S., Zaman, M., Kim, H.-D., Grantcharova, V., Lauffenburger, D., and White, F. (2006). Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol 2:54. PMID:17016520
   PDFExternal link to article
8. Gaudet, S., Janes, K. A., Albeck, J. G., Pace, E. A., Lauffenburger, D. A., and Sorger, P. K. (2005). A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics 4, 1569-1590. PMID:16030008
   PDFExternal link to articleSupplemental material
9. Janes, K. A., Albeck, J. G., Gaudet, S., Sorger, P. K., Lauffenburger, D. A., and Yaffe, M. B. (2005). A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310, 1646-1653. PMID:16339439
   PDFExternal link to articleSupplemental material
10. Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D., and Nolan, G. (2005). Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data. Science 308, 523-529. PMID:15845847
    PDFExternal link to article

Full list by Author, published, accepted, or in press

2008

1. Albeck, J. G., Burke, J. M., Aldridge, B., Zhang, M. S., Lauffenburger, D. A., and Sorger, P. K. (2008; in press). Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell.
2. Apgar, J. R., Toettcher, J. E., Endy, D., White, F., and Tidor, B. (2008; in press). Stimulus Design for Model Selection and Validation in Cell Signaling. PLoS Biol.
3. Cosgrove, B., Griffith, L. G., and Lauffenburger, D. A. (2008; in press). Fusing Systems Biology and Tissue Engineering Toward Fulfilling their Promise. Cellular & Molecular Bioengineering.
4. Squires, T. M., Messinger, R. J., and Manalis, S. R. (2008; in press). Making it stick: convection, reaction, and diffusion in surface based biosensors. . Nature Biotechnology.
5. Saez-Rodriguez, J., Goldsipe, A., Muhlich, J., Alexopoulos, L. G., Millard, B., Lauffenburger, D. A., and Sorger, P. K. (2008). Flexible Informatics for Linking Experimental Data to Mathematical Models via DataRail. Bioinformatics. PMID:18218655
   PDFExternal link to articleDownload DataRail
6. Trujillo-Provencio, C., Sultemeier, D., Powers, T., and Serrano, E. E. (2008). RNA isolation from Xenopus inner ear sensory endorgans for transcriptional profiling and molecular cloning, In Methods in Molecular Biology: Auditory and Vestibular Research, B. Sokolowski, ed. (Humana Press, Inc.).
7. Wang, Y.-C., and Han, J. (2008). Pre-binding dynamic range and sensitivity enhancement for immuno-sensors using nanofluidic preconcentrator. Lab on a Chip. DOI:10.1039/b717220f
   PDFExternal link to article

2007

1. Albrecht, J. W., El-Ali, J., and Jensen, K. F. (2007). Cascaded free-flow isoelectric focusing for improved focusing speed and resolution. Anal Chem 79, 9364-9371. PMID:17994708
   PDFExternal link to article
2. Albrecht, J. W., and Jensen, K. F. (2007). Patent Application: Isoelectric focusing systems and methods. MIT Case No.: 12421.
3. Burg, T., Godin, M., Knudsen, S., Shen, W., Carlson, G., Foster, J., Babcock, K., and Manalis, S. (2007). Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446, 1066-1069. PMID:17460669
   PDFExternal link to articleSupplemental material
4. Chellappan, S., Kiran Kumar Reddy, G. S., Ali, A., Nalam, M. N., Anjum, S. G., Cao, H., Kairys, V., Fernandes, M. X., Altman, M. D., Tidor, B., Rana, T. M., Schiffer, C. A., and Gilson, M. K. (2007). Design of Mutation-resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis. Chem Biol Drug Des 69, 298-313. PMID:17539822
   PDFExternal link to article
5. Chunara, R., Burg, T. P., Payer, K., Dextras, P., and Manalis, S. (2007). Suspended microchannel resonators with integrated electronic readout for biomolecular and single cell analysis, In The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007) (Paris, France).
   PDF
6. Chunara, R., Godin, M., Knudsen, S. M., and Manalis, S. R. (2007). Mass-based readout for agglutination assays. Applied Physics Letters. DOI:10.1063/1.2806197
   External link to article
7. Fu, X., Apgar, J. R., and Keating, A. E. (2007). Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL. J Mol Biol 371, 1099-1117. PMID:17597151
   PDFExternal link to article
8. Godin, M., Bryan, A. K., Burg, T. P., Babcock, K., and Manalis, S. R. (2007). Measuring the mass, density, and size of particles and cells using a suspended microchannel resonator. Applied Physics Letters 91, 123121. DOI:10.1063/1.2789694
   PDFExternal link to article
9. Grover, W. H., Weng, Y. C., and Manalis, S. R. (2007). A microfluidic autosampler with true Teflon valves: Design and application to the suspended microchannel resonator mass sensor, In The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007) (Paris, France).
   PDF
10. Huang, P. H., Mukasa, A., Bonavia, R., Flynn, R., Brewer, Z., Cavenee, W., Furnari, F., and White, F. (2007). Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci U S A 104, 12867-12872. PMID:17646646
    PDFExternal link to article
11. Kemp, M. L., Wille, L., Lewis, C. L., Nicholson, L. B., and Lauffenburger, D. A. (2007). Quantitative Network Signal Combinations Downstream of TCR Activation Can Predict IL-2 Production Response. J Immunol 178, 4984-4992. PMID:17404280
    PDFExternal link to article
12. Kim, S. J., Wang, Y.-C., Lee, J. H., Jang, H., and Han, J. (2007). Concentration Polarization and Nonlinear Electrokinetic Flow near a Nanofluidic Channel. Physical Review Letters 99. PMID:17678369
    PDFExternal link to article
13. Linding, R., Jensen, L. J., Ostheimer, G. J., van Vugt, M. A., Jørgensen, C., Miron, I. M., Diella, F., Colwill, K., Taylor, L., Elder, K., Metalnikov, P., Nguyen, V., Pasculescu, A., Jin, J., Park, J. G., Samson, L. D., Woodgett, J. R., Russell, R. B., Bork, P., Yaffe, M. B., and Pawson, T. (2007). Systematic discovery of in vivo phosphorylation networks. Cell 129, 1415-1426. PMID:17570479
    PDFExternal link to article
14. Miller-Jensen, K., Janes, K. A., Brugge, J. S., and Lauffenburger, D. A. (2007). Common effector processing mediates cell-specific responses to stimuli. Nature 448, 604-608. PMID:17637676
    PDFExternal link to article
15. Quick, Q. A., and Serrano, E. E. (2007). Cell proliferation during the early compartmentalization of the Xenopus laevis inner ear. Int J Dev Biol 51, 201-209. PMID:17486540
    PDFExternal link to article
16. Sakarya, O., Armstrong, K. A., Adamska, M., Adamski, M., Wang, I. F., Tidor, B., Degnan, B. M., Oakley, T. H., and Kosik, K. S. (2007). A post-synaptic scaffold at the origin of the animal kingdom. PLoS ONE 2. PMID:17551586
    PDFExternal link to article
17. Tian, Y., Kolb, R., Hong, J. H., Carroll, J., Li, D., You, J., Bronson, R., Yaffe, M. B., Zhou, J., and Benjamin, T. (2007). TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol 27, 6383-6395. PMID:17636028
    PDFExternal link to article
18. Wang, Y.-C., Liu, V., and Han, J. (2007). Nanofluidic preconcentration device for sensitive and wide dynamic range immunosensing, In The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007) (Paris, France).
    PDF
19. Wilker, E. W., van Vugt, M. A., Artim, S. A., Huang, P. H., Petersen, C. P., Reinhardt, H. C., Feng, Y., Sharp, P. A., Sonenberg, N., White, F. M., and Yaffe, M. B. (2007). 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature 446, 329-332. PMID:17361185
    PDFExternal link to article
20. Wilkins, A. K., Barton, P. I., and Tidor, B. (2007). The Per2 Negative Feedback Loop Sets the Period in the Mammalian Circadian Clock Mechanism. PLoS Comput Biol 3, e242. PMID:18085817
    PDFExternal link to article
21. Wille, L., Kemp, M., Sandy, P., Lewis, C., and Lauffenburger, D. (2007). Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Molecular Immunology 44, 3085-3091. PMID:17418417
    PDFExternal link to article
22. Wolf-Yadlin, A., Hautaniemi, S., Lauffenburger, D. A., and White, F. M. (2007). Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A. PMID:17389395
    PDFExternal link to article
23. Yaffe, M. B., and White, F. M. (2007). Signaling netwErks get the global treatment. Genome Biol 8, 202. PMID:17274840
    PDFExternal link to article
24. Ye, L., Zhang, M., Alexopoulos, L. G., Sorger, P. K., and Jensen, K. F. (2007). Microfluidic devices for studying the response of adherent cells under short time stimuli treatment, Paper presented at: The 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2007) (Paris, France).
    PDF

2006

1. Adamo, A., and Jensen, K. F. (2006). Microfluidics for controlled single cell microinjection, Paper presented at: The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006) (Tokyo, Japan).
   PDF
2. Adiwijaya, B. S., Barton, P. I., and Tidor, B. (2006). Biological network design strategies: discovery through dynamic optimization. Mol Biosyst 2, 650-659. PMID:17216046
   PDFExternal link to article
3. Albeck, J., Macbeath, G., White, F., Sorger, P., Lauffenburger, D., and Gaudet, S. (2006). Collecting and organizing systematic sets of protein data. Nature Reviews Molecular Cell Biology 7, 803-812. PMID:17057751
   PDFExternal link to article
4. Albrecht, J., and Jensen, K. F. (2006). Multi-stage free-flow isoelectric focusing for enhanced separation speed and resolution, Paper presented at: The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006) (Tokyo, Japan).
   PDF
5. Albrecht, J. W., and Jensen, K. F. (2006). Micro free flow isoelectric focusing enhanced by active cooling and functionalized gels. Electrophoresis 27, 4960-4969. PMID:17117380
   PDFExternal link to article
6. Aldridge, B., Burke, J., Lauffenburger, D., and Sorger, P. (2006). Physicochemical modelling of cell signalling pathways. Nature Cell Biology 8, 1195-1203. PMID:17060902
   PDFExternal link to article
7. Aldridge, B. B., Haller, G., Sorger, P. K., and Lauffenburger, D. A. (2006). Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage) 153, 425-432. PMID:17186704
   PDFExternal link to article
8. Burg, T. P., Mirza, A. R., Milovic, N., Tsau, C. H., Popescu, G. A., Foster, J. S., and Manalis, S. R. (2006). Vacuum-packaged suspended microchannel resonant mass sensor for biomolecular detection. Microelectromechanical Systems, Journal of 15, 1466-1476. DOI:10.1109/JMEMS.2006.883568
   PDFExternal link to article
9. El-Ali, J., and Jensen, K. F. (2006). Microcarrier enabled microfluidic assays of anchorage dependant cells, Paper presented at: The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2006) (Tokyo, Japan).
   PDF
10. El-Ali, J., Sorger, P. K., and Jensen, K. F. (2006). Cells on chips. Nature 442, 403-411. PMID:16871208
    PDFExternal link to article
11. Fitzgerald, J. B., Schoeberl, B., Nielsen, U. B., and Sorger, P. K. (2006). Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2, 458-466. PMID:16921358
    PDFExternal link to article
12. Gervais, T., El-Ali, J., Günther, A., and Jensen, K. F. (2006). Flow-induced deformation of shallow microfluidic channels. Lab Chip 6, 500-507. PMID:16572212
    PDFExternal link to article
13. Gervais, T., and Jensen, K. (2006). Mass transport and surface reactions in microfluidic systems. Chemical Engineering Science 61, 1102-1121. DOI:10.1016/j.ces.2005.06.024 10.1016/j.ces.2005.06.024
    PDFExternal link to article
14. Heinrichs, A., Kritikou, E., Pulverer, B., and Raftopoulou, M., eds. (2006). Systems biology: a user's guide (New York, NY: Nature Publishing Group).
    External link to article
15. Hong, J. H., and Yaffe, M. B. (2006). TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle 5, 176-179. PMID:16397409
    PDFExternal link to article
16. Hua, F., Hautaniemi, S., Yokoo, R., and Lauffenburger, D. A. (2006). Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways. J R Soc Interface 3, 515-526. PMID:16849248
    PDFExternal link to article
17. Ideker, T., Winslow, L., and Lauffenburger, D. A. (2006). Bioengineering and Systems Biology. Annals of Biomedical Engineering 34, 257-264. PMID:16929563
    PDFExternal link to article
18. Janes, K., and Yaffe, M. (2006). Data-driven modelling of signal-transduction networks. Nature Reviews Molecular Cell Biology 7, 820-828. PMID:17057752
    PDFExternal link to article
19. Janes, K. A., Gaudet, S., Albeck, J. G., Nielsen, U. B., Lauffenburger, D. A., and Sorger, P. K. (2006). The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124, 1225-1239. PMID:16564013
    PDFExternal link to article
20. Janes, K. A., and Lauffenburger, D. A. (2006). A biological approach to computational models of proteomic networks. Curr Opin Chem Biol 10, 73-80. PMID:16406679
    PDFExternal link to article
21. Kim, J. E., and White, F. M. (2006). Quantitative analysis of phosphotyrosine signaling networks triggered by CD3 and CD28 costimulation in jurkat cells. J Immunol 176, 2833-2843. PMID:16493040
    PDFExternal link to article
22. Knight, V. B., and Serrano, E. E. (2006). Tissue and Species Differences in the Application of Quantum Dots as Probes for Biomolecular Targets in the Inner Ear and Kidney. Nanobioscience, IEEE Transactions on 5, 251-262. PMID:17181024
    PDFExternal link to article
23. Miller-Jensen, K., Janes, K. A., Wong, Y. L., Griffith, L. G., and Lauffenburger, D. A. (2006). Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. J Cell Sci 119, 3788-3798. PMID:16940353
    PDFExternal link to article
24. Schmelzle, K., and White, F. M. (2006). Phosphoproteomic approaches to elucidate cellular signaling networks. Curr Opin Biotechnol 17, 406-414. PMID:16806894
    PDFExternal link to article
25. Wolf-Yadlin, A., Kumar, N., Zhang, Y., Hautaniemi, S., Zaman, M., Kim, H.-D., Grantcharova, V., Lauffenburger, D., and White, F. (2006). Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol 2:54. PMID:17016520
    PDFExternal link to article
26. Yeang, C. H., and Jaakkola, T. (2006). Modeling the combinatorial functions of multiple transcription factors. J Comput Biol 13, 463-480. PMID:16597252
    PDFExternal link to article

2005

1. Albrecht, J., Gaudet, S., and Jensen, K. F. (2005). Rapid free flow isoelectric focusing via novel electrode structures, Paper presented at: The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2005) (Boston, USA).
   PDF
2. Altman, M. D., Bardhan, J. P., White, J. K., and Tidor, B. (2005). An Accurate Surface Formulation for Biomolecule Electrostatics in Non-Ionic Solutions, Paper presented at: Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the. PMID:17282038
   PDFExternal link to article
3. El-Ali, J., Gaudet, S., Günther, A., Sorger, P. K., and Jensen, K. F. (2005). Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem 77, 3629-3636. PMID:15924398
   PDFExternal link to article
4. El-Ali, J., Gaudet, S., Murhpy, Nielsen, U. B., and Jensen, K. F. (2005). Microfluidic device with integrated antibody arrays for cell signaling analysis, Paper presented at: The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2005) (Boston, USA).
   PDF
5. Gaudet, S., Janes, K. A., Albeck, J. G., Pace, E. A., Lauffenburger, D. A., and Sorger, P. K. (2005). A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics 4, 1569-1590. PMID:16030008
   PDFExternal link to articleSupplemental material
6. Gervais, T., Tsau, C., Ali, E., Manalis, S. R., and Jensen, K. F. (2005). Convection-limited Surface Transport In Nanofluidic Channels, Paper presented at: The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2005).
   PDF
7. Goldberg, I. G., Allan, C., Burel, J. M., Creager, D., Falconi, A., Hochheiser, H., Johnston, J., Mellen, J., Sorger, P. K., and Swedlow, J. R. (2005). The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol 6. PMID:15892875
   PDFExternal link to article
8. Hong, J. H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., Hopkins, N., and Yaffe, M. B. (2005). TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074-1078. PMID:16099986
   PDFExternal link to article
9. Hua, F., Cornejo, M. G., Cardone, M. H., Stokes, C. L., and Lauffenburger, D. A. (2005). Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. J Immunol 175, 985-995. PMID:16002698
   PDFExternal link to article
10. Janes, K. A., Albeck, J. G., Gaudet, S., Sorger, P. K., Lauffenburger, D. A., and Yaffe, M. B. (2005). A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310, 1646-1653. PMID:16339439
    PDFExternal link to articleSupplemental material
11. Kim, J. E., Tannenbaum, S. R., and White, F. M. (2005). Global phosphoproteome of HT-29 human colon adenocarcinoma cells. J Proteome Res 4, 1339-1346. PMID:16083285
    PDFExternal link to article
12. Lu, H., and Jensen, K. (2005). Cellular and Subcellular Analysis on Chip, In Lab-on-Chips for Cellomics, pp. 273-298. DOI:10.1007/978-1-4020-2975-2_11
    PDFExternal link to article
13. Lu, H., Schmidt, M. A., and Jensen, K. F. (2005). A microfluidic electroporation device for cell lysis. Lab Chip 5, 23-29. PMID:15616736
    PDFExternal link to article
14. Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D., and Nolan, G. (2005). Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data. Science 308, 523-529. PMID:15845847
    PDFExternal link to article
15. Shults, M. D., Janes, K. A., Lauffenburger, D. A., and Imperiali, B. (2005). A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nat Methods 2, 277-283. PMID:15782220
    PDFExternal link to article
16. Sorger, P. K. (2005). A reductionist's systems biology: opinion. Curr Opin Cell Biol 17, 9-11. PMID:15661513
    PDFExternal link to article
17. Wang, Y.-C., Tsau, C. H., Burg, T. P., Manalis, S., and Han, J. (2005). Efficient Biomolecule Pre-concentration by Nanofilter-triggered Electrokinetic Trapping, In The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS2005) (Boston, MA).
    PDF
18. Wilker, E. W., Grant, R. A., Artim, S. C., and Yaffe, M. B. (2005). A structural basis for 14-3-3sigma functional specificity. J Biol Chem 280, 18891-18898. PMID:15731107
    PDFExternal link to article
19. Yeang, C. H., Mak, H. C., McCuine, S., Workman, C., Jaakkola, T., and Ideker, T. (2005). Validation and refinement of gene-regulatory pathways on a network of physical interactions. Genome Biol 6. PMID:15998451
    PDFExternal link to article
20. Zhang, Y., Wolf-Yadlin, A., Ross, P. L., Pappin, D. J., Rush, J., Lauffenburger, D. A., and White, F. M. (2005). Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics 4, 1240-1250. PMID:15951569
    PDFExternal link to article

2004

1. Brown, G. E., Stewart, M. Q., Bissonnette, S. A., Elia, A. E., Wilker, E., and Yaffe, M. B. (2004). Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem 279, 27059-27068. PMID:15102856
   PDFExternal link to article
2. Janes, K. A., Kelly, J. R., Gaudet, S., Albeck, J. G., Sorger, P. K., and Lauffenburger, D. A. (2004). Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol 11, 544-561. PMID:15579231
   PDFExternal link to article
3. Kim, J. E., and Tannenbaum, S. R. (2004). Insulin regulates cleavage of procaspase-9 via binding of X chromosome-linked inhibitor of apoptosis protein in HT-29 cells. Cancer Res 64, 9070-9075. PMID:15604274
   PDFExternal link to article
4. Kim, J.-E., and Tannenbaum, S. (2004). S-Nitrosation Regulates the Activation of Endogenous Procaspase-9 in HT-29 Human Colon Carcinoma Cells. J Biol Chem 279, 9758-9764. PMID:14701803
   PDFExternal link to article
5. Lu, H., Gaudet, S., Schmidt, M. A., and Jensen, K. F. (2004). A microfabricated device for subcellular organelle sorting. Anal Chem 76, 5705-5712. PMID:15456289
   PDFExternal link to article
6. Said, M. R., Begley, T. J., Oppenheim, A. V., Lauffenburger, D. A., and Samson, L. D. (2004). Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101, 18006-18011. PMID:15608068
   PDFExternal link to article
7. Savran, C. A., Knudsen, S. M., Ellington, A. D., and Manalis, S. R. (2004). Micromechanical detection of proteins using aptamer-based receptor molecules. Anal Chem 76, 3194-3198. PMID:15167801
   PDFExternal link to article

2003

1. Burg, T. P., and Manalis, S. R. (2003). Suspended microchannel resonators for biomolecular detection. Applied Physics Letters 83, 2698-2700. DOI:10.1063/1.1611625
   PDFExternal link to article
2. Janes, K. A., Albeck, J. G., Peng, L. X., Sorger, P. K., Lauffenburger, D. A., and Yaffe, M. B. (2003). A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics 2, 463-473. PMID:12832460
   PDFExternal link to article