Applying modeling and measurement to primary and differentiated human cells
We are utilizing many of the methods and approaches developed in CDP to study primary and differentiated cells with a key role in health and disease. Specifically, our goals are as follows:
- To determine why TNFα is a pro-survival rather than a pro-death factor in human neutrophils and to dissect multi-factorial control over the enzyme responsible for neutrophil-mediated cell-killing activity (the reactive oxygen species (ROS)-generating enzyme NADPH oxidase).
- To study the activities of growth, death, and inflammatory ligands in liver cells, where they play profound roles in the balance between cell survival and self-renewal under a variety of normal and pathological conditions, in particular in liver cancer.
- To probe the mechanisms that control T-cell survival and proliferation with particular emphasis on T Cell Receptors (TCR) and interleukins.
