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Scott Manalis

Biosketch

Ph.D. in Applied Physics • 1998 Stanford University

The Manalis laboratory applies standard silicon microfabrication principles to develop quantitative and real-time measurement techniques for detecting biomolecules and analyzing single cells.

Manalis lab website

Research summary

How cells grow in size is a complex problem. Size arises from an interplay between cell growth (the accumulation of mass) and cell division (the partitioning of this mass), but the relationship between cell growth and division is not well characterized. Progress in understanding cell growth and cell size control has been hampered by the lack of sufficiently precise, single-cell measurements.

We have recently developed a technology that can measure the mass of a mammalian cell with femtogram resolution to a precision of 0.01%. This approach, called the suspended microchannel resonator (SMR), measures particles in real-time as they flow through a hollow cantilever. The SMR solves the problem of signal degradation from viscous drag by placing the fluid inside the resonator instead of immersing the resonator in the fluid.

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