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Mark Fleury

Education

École Polytechnique Fédérale de Lausanne Lausanne, Switzerland Ph.D. Bioengineering June 2007 Research Advisor: Dr. Melody A. Swartz Thesis: “Effects of Dynamic Environments on Extracellular Morphogen Gradients”

Northwestern University Evanston, IL USA M.S. Chemical Engineering December 2003 Research Advisor: Dr. Melody A. Swartz Researched effects of interstitial flow on cell migration and signaling

Kansas State University Manhattan, KS USA B.S. Chemical Engineering December 1995

Work Experience

Massachusetts Institute of Technology Cambridge, MA Postdoctoral Scientist Research Advisor: Dr. Douglas A. Lauffenburger December 2007-Present
Study of cell-signaling networks in the context of cytokine treatment of immune cells. High throughput flow cytometry and phospho kinase assays RT-PCR Partial Least Squares Data Regression and cluster analysis

National Academies Washington, DC Christine Mirzayan Public Policy Fellow, Center for Advancement of Scholarship on Engineering Education (CASEE) September-November 2007
Researched and wrote a review paper on assessments of instructional behaviors and redesigned CASEE website.

École Polytechnique Fédérale de Lausanne Lausanne, Switzerland Research Assistant, Laboratory for Morphogenesis and Mechanobiology January 2004-June 2007
Computational modeling of cell-level biophysical forces, mass transport and reaction kinetics along with experimental work on the effects of interstitial fluid flow on cell migration and signaling. Mammalian cell culture in both traditional cultures and 3-dimensional matrixes including use of custom fabricated flow chambers. Live tumor cell migration studies Mathematical modeling using Matlab, ADINA and COMSOL. Involved in lab startup and equipment procurement Managed lab microscopy facility (purchasing, training, and maintenance) which included wide-field, confocal, and fluorescent stereomicroscopes. Peer review of scientific articles Teaching assistant

Northwestern University Evanston, IL USA Research Assistant, Integrative Cell and Tissue Mechanics Laboratory November 2002-January 2004
See EPFL experience above.

Cargill Incorporated, North American Corn Milling Blair, NE USA Project Engineer September 1999-July 2002
Handled large-scale capital projects with responsibilities that ranged from economic feasibility studies, to actual design, purchasing, construction oversight, commissioning, and startup. Responsible for $28 million worth of projects between Sept. 1999- July 2002 Designed wastewater methane off-gas recovery project Designed complete wastewater treatment facility for industrial wastewater Managed outside contracts and contractors Preparation of project proposals comprising planning, economics feasibility, and environmental licensing Interaction with various levels of organization from state regulatory personnel to internal divisional managers to operations technicians Trained and managed engineering interns and new hires Licensed as a Professional Engineer in State of Nebraska

Cargill Incorporated, North American Corn Milling Eddyville, IA USA Process Engineer-High Fructose Corn Syrup Refinery February 1996–September 1999
Experience included training as a shift operator, which further developed into front line shift supervision. Responsibilities included troubleshooting, debottlenecking and optimization of unit operations within the refinery. Also involved in small-scale project engineering. Active in day to day troubleshooting Performed technical training for facility Assisted in development of divisional engineering standards Experience with food safety , HAACP, and GMP programs Participated in PSM implementation

Bayer Corporation Kansas City, MO USA Environmental engineering intern Summer 1995
Assisted in PM-10 emissions testing

Directorate of Environment and Safety, Fort Riley Military Base Ft. Riley, KS USA Environmental engineering intern Summer 1994
Aided in collection, cataloging, and disposal of hazardous wastes Worked with both civilian and enlisted personnel

Publications

Fleury ME, NL Fortenberry. Submitted. “Assessment of instructional behavior-a literature review.”

Swartz, MA, ME Fleury. 2007. “Interstitial Flow and Its Effects in Soft Tissues,” Annual Reviews of Biomedical Engineering 9:15.1-15.28.

Shields JD, ME Fleury* C Yong, AA Tomei, GJ Randolf, MA Swartz. 2007. “Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signalling,” Cancer Cell. 11(6):526-538. *Co-First Author

Fleury ME, KC Boardman, MA Swartz. 2006. “Autologous morphogen gradients by subtle interstitial flow and matrix interactions,“ Biophys. J. 91(1):113-121.

Helm CLE, ME Fleury, AH Zisch, F Boschetti, MA Swartz. 2005. “Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism,” Proc. Natl. Acad. Sci. U. S. A. 102:15779-15784.

Professional memberships and licenses

Licensed as professional chemical engineer (P.E.) in Nebraska
American Association for the Advancement of Science (AAAS)
American Institute of Chemical Engineers (AIChE)
American Chemical Society (ACS)
Biomedical Engineering Society (BMES)
Tau Beta Pi

Awards

2008 Servier Award in Microcirculation for article “Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling” in ‘Cancer Cell’

2006 BMES Graduate Student Research Award

Languages

English (native), French (fluent), and German (elementary)