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David C. Clarke

Education

Ph.D. Chemical Engineering. University of Colorado at Boulder (2008)
Thesis: The Quantitative study of TGF-β/Smad signaling dynamics; Supervisor: Dr. Xuedong Liu

M.Sc. Kinesiology. University of Waterloo, Waterloo, ON, Canada (2002)
Thesis: The Application of In Vivo Electrotransfection to the Study of Plasma Membrane Associated Fatty Acid Binding Protein; Supervisor: Dr. Arend Bonen

B.Sc. (Honours) Kinesiology. Laurentian University, Sudbury, ON, Canada (2000)

Research Interests

I am interested in studying mammalian cell signal transduction using quantitative approaches. Within this theme, my postdoctoral research involves the following projects: 1) constrained fuzzy logic modeling of hepatocellular carcinoma cell signaling, 2) mixed modeling techniques for statistical analysis of multiplexed cell signaling data and 3) investigating biological and statistical reasons underlying a paradox of systems biology in which everything seems to regulate everything.

Publications

Peer-reviewed Publications
Clarke, D. C., Brown, M. L., Erickson, R. A., Shi, Y., Liu, X. (2009). Transforming Growth Factor-β depletion is the primary determinant of Smad signaling kinetics. Molecular and Cellular Biology, 29(9): 2443-2455.

Clarke, D. C. and Liu, X. (2008). Decoding the quantitative nature of Transforming Growth Factor-β signaling. Trends in Cell Biology. 18(9): 430-42.

Zhu, S., Wang, W., Clarke, D. C., Liu, X. (2007). Activation of Mps1 promotes Transforming Growth Factor-β-independent Smad signaling. Journal of Biological Chemistry. 282(25): 18327-18338.

Clarke, D. C., Betterton, M. D., Liu, X. (2006). Systems theory of Smad signaling. Systems Biology (Stevenage). 153(6): 412-424.

Clarke, D. C., Miskovic, D., Han, X.-X., Calles-Escandon, J., Glatz, J. F. C., Luiken, J. J. F. P., Heikkila, J. J., Bonen, A. (2004). Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism. Physiological Genomics. 17: 31-37.

Book Chapters
Clarke, D. C. and Liu, X. Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting. Methods in Molecular Biology, in press.

Lay Publications
Clarke, D.C., and Ricci, M. (2009). Calculated performance: Using quantitative models to optimize your training. Triathlete Magazine, January 2009 edition, p.119.