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Albert YeBiosketchPhD candidate, MacBeath Lab, Department of Molecular and Cellular Biology, Harvard University My thesis research focuses on understanding the systems biology of the DNA damage response in breast cancer progression. Research SummaryThe DNA Damage Response (DDR) to single and double-stranded breaks is well-studied in eukaryotes. Largely mediated by phosphorylation events, the DDR can induce several cell-cycle checkpoints as a survival phenotype, or apoptosis and senescence as an anti-proliferation phenotype. Unfortunately, understanding of the DDR on a systems level is limited. I seek to use lysate microarray technology to understand how information flows in the DDR. Important questions are: which nodes are the most sensitive for phenotypic response, are there unknown pathway feedback interactions, and how does the network change over the course of tumor progression. Primary CollaboratorMichael Lee, Yaffe lab |
