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Emiko Fire

Current position: Mentor Scientist, Science Club for Girls

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Research: Understanding Interaction Specificity Among Bcl-2 Proteins

The Bcl-2 protein family is important in regulating apoptosis via protein-protein interactions. Bcl-2 family members can be pro-apoptotic or anti-apoptotic and classified into three subfamilies: the anti-apoptotic Bcl-2-like, the pro-apoptotic Bax-like, and the pro-apoptotic BH3-only subfamilies. I have examining the specificity of the interactions between anti-apoptotic proteins (BCL-XL and MCL-1) and the BH3 regions of pro-apoptotic proteins. I use X-ray cystallography and mutant binding studies to explore these specificity determinants.

Collaborators

Keating lab: Stefano Gulla and Sanjib Dutta
Sorger lab: Carlos Lopez

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This page last modified on July 3rd, 2012