Home / People / Alumni / Alejandro Wolf-Yadlin

Alejandro Wolf-Yadlin

Current position: Assistant Professor, University of Washington

LinkedIn Profile

Education

2007 – Ph.D. Biological Engineering Division, Massachusetts Institute of Technology.

2001 Master in Engineering Sciences Degree in Chemical Engineering. Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. Santiago, Chile. (Master’s thesis research performed in the Biochemistry Department of Lund University, Lund Sweden)

2001 Civil Engineering Degree in Biotechnology Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. Santiago, Chile.

1999 Bachelor in Engineering Sciences Degree in Biotechnology. Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. Santiago, Chile. (School of Physical and Mathematical Sciences. University of Chile. Santiago, Chile)

Research

I am interested in the development and application of novel proteomics tools to understand cellular signaling networks. The goal of my research is to produce high-throughput and high-quality data that will allow us to dissect differences in cellular signaling downstream of various receptor tyrosine kinases and highlight nodes as potential therapy targets.

References

Wolf-Yadlin, A, Sevecka, M & MacBeath, G “Dissecting Protein Function and Signaling Using Protein Microarrays”. Manuscript submitted, Curr. Opin. Chem. Biol. (2009).
Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G. “Linear combinations of docking affinities explain quantitative differences in RTK signaling”. Mol Syst Biol. 2009;5:235. Epub 2009 Jan 20.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. “Multiple Reaction Monitoring for Robust Quantitative Proteomic Analysis of Cellular Signaling Networks”. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5860-5. Epub 2007 Mar 26.
Wolf-Yadlin A, Zhang Y, White FM.. “Quantitative Proteomic Analysis of Phosphotyrosine-Mediated Cellular Signaling Networks”. Methods Mol Biol. 2007; 359(14):203-212.
Kumar N, Wolf-Yadlin A, White FM, Lauffenburger DA. “Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data”. PLoS Comput Biol. 2007 Jan 5;3(1):e4. Epub 2006 Nov 21.
Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. “Effects of HER2 overexpression on cell signaling networks governing proliferation and migration”. Mol Syst Biol. 2006;2:54. Epub 2006 Oct 3.
Wolf-Yadlin A, Zhang Y, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM. “ Time-resolved mass spectrometry of tyrosine phosphorylation sites in the EGF receptor signaling network reveals dynamic modules”. Mol Cell Proteomics. 2005 Sep;4(9):1240-50. Epub 2005 Jun 11.
Berggren K, Wolf A, Asenjo JA, Andrews BA, Tjerneld F. “The surface exposed amino acid residues of monomeric proteins determine the partitioning in aqueous two-phase systems”. Biochim Biophys Acta. 2002 Apr 29;1596(2):253-68.

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