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CDP Sabbatical Visitors

kimberly_jackson1Kimberly Jackson, Spelman College: The Jackson lab investigates dibenzoylmethane (DBM), a minor component of licorice, as a novel therapeutic agent for advanced or hormone-refractory prostate cancer. Dr. Jackson will use her CDP sabbatical to learn systems biology techniques to examine how DBM regulates the function of androgen receptors (AR), which play a key role in tumor development and disease progression of the prostate. In particular, Dr. Jackson will spend June 2010 using microarray technology to identify DBM-regulated genes in the AR signaling pathway that are involved in prostate cancer growth regulation and differentiation.

Previous visitors
Professor Carlos Ríos Velázquez, the University of Puerto Rico in Mayagüez: Dr. Velázquez’ research interests are in microbial biotechnology and bioprospecting, development of biosensors for toxins and toxin-producing microbes, and the use of functional genomics and combinatorial chemistry in detection of anti-microbial agents. He and two of his UPRM students spent three months at MIT during the summer of 2005. Working with Dr. Rebecca Fry, Director of the BioMicro Center and Prof. Leona Samson, Director of MIT’s Center for Environmental Health Sciences, they took a systems biology approach to the study of cellular responses to DNA damage. Environmental disturbances such as exposure to toxic agents or UV can cause DNA damage, activating genetic cascades with physiological consequences effecting recovery or survival. Transcriptional profiling, genomic phenotyping, interactome mapping and sub-cellular localization have been employed to understand specific cells’ responses, but information on whole-cell modulation in response to stimuli is still needed. The team developed a high-throughput system using a whole Saccharomyces cerevisiae genome GFP fusion library to analyze the global proteome dynamics after addition of the DNA damaging agent Methyl Methane Sulfonate (MMS).

Professor Elba Serrano, New Mexico State University: At NMSU, Dr. Serrano’s lab studies the development of the nervous system, with an emphasis on the sensory systems responsible for hearing and balance. Her research employs a broad range of methods, including molecular biology, anatomy, genetics, informatics, biophotonics, tissue culture, bioimaging, and electrophysiology. From September 2005-June 2006, Dr. Serrano interacted with several CDP and CSBi investigators, planning research projects. Several of her NMSU students came for shorter periods and participated in this research.

Professor Shubha Govind, City College of New York: Dr. Govind started her CDP Sabbatical in October 2008 as a Visiting Professor at Harvard Medical School’s Department of Systems Biology. The Govind lab has broad research interests, including the role of NF-κB signaling in hematopoiesis, inflammation, and pathogen virulence and parasitic evasion of the host immune response. Dr. Govind’s research relies heavily on use of Drosophila as an experimental model organism, but her focus is expanding to include computational and systems analysis of the complex processes under study in her laboratory.

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This page last modified on June 30th, 2010